Search results for " health status"

showing 10 items of 26 documents

Impact of t-PA administration on brain BDNF levels in physiological conditions and in circulating BDNF levels in ischemic conditions : Human and anim…

2014

Our objective was to test the hypothesis that the beneficial effect of the administration of the recombinant form of tissue plasminogen activator (rt-PA) in ischemic stroke patient not only results from its fibrinolytic activity but also from its ability to increase brain-derived neurotrophic factor (BDNF) in the brain. To this end, we conducted an initial study to evaluate the effect of rt-PA on brain BDNF levels in healthy animals. In a second study, we investigated the effect of rt-PA on serum BDNF levels in ischemic stroke patients and in animals subjected to permanent focal cerebral ischemia. Blood samples were obtained from patient on admission (D0), D1, D7 and D90 after stroke and in…

researchProduct

Symptom variability and control in COPD: Advantages of dual bronchodilation therapy

2017

Abstract Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder characterized by usually progressive development of airflow obstruction that is not fully reversible. While most patients will experience symptoms throughout the day or in the morning upon awakening, many patients do not experience their symptoms as constant but report variability in symptoms during the course of the day or over time. Symptom variability adversely affects patients' health status and increases the risk of COPD exacerbations. Methods We examined data from the literature on symptom variability and control in patients with COPD, with focus on the use of inhaled bronchodilator therapy wi…

Aclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Pulmonary and Respiratory MedicineAclidiniumHealth StatusVital CapacityHealth StatuPulmonary Disease Chronic Obstructive0302 clinical medicineForced Expiratory VolumeFormoterol FumarateBronchodilatorBronchodilationFormoterol030212 general & internal medicineAclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Administration Inhalation; Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Disease Progression; Dose-Response Relationship Drug; Drug Therapy Combination; Forced Expiratory Volume; Formoterol Fumarate; Health Status; Humans; Muscarinic Antagonists; Pulmonary Disease Chronic Obstructive; Quality of Life; Treatment Outcome; Tropanes; Vital CapacityLung functionCOPDbiologyChronic obstructive pulmonary diseaseTropaneLamaBronchodilator AgentsMuscarinic AntagonistTreatment OutcomeInhalationAdministrationCombinationDisease ProgressionDrug Therapy CombinationDrugHumanmedicine.drugAdrenergic beta-2 Receptor AgonistPulmonary and Respiratory MedicineChronic Obstructivemedicine.medical_specialtymedicine.drug_classSymptom variabilitySocio-culturaleMuscarinic AntagonistsSettore MED/10 - Malattie Dell'Apparato RespiratorioDose-Response RelationshipPulmonary Disease03 medical and health sciencesDrug TherapyAdministration InhalationmedicineHumansIntensive care medicineAdrenergic beta-2 Receptor AgonistsBronchodilator AgentDose-Response Relationship Drugbusiness.industryMuscarinic antagonistDual bronchodilator therapymedicine.diseasebiology.organism_classificationLung functionrespiratory tract diseasesAclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Administration Inhalation; Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Disease Progression; Dose-Response Relationship Drug; Drug Therapy Combination; Forced Expiratory Volume; Formoterol Fumarate; Health Status; Humans; Muscarinic Antagonists; Pulmonary Disease Chronic Obstructive; Quality of Life; Treatment Outcome; Tropanes; Vital Capacity; Pulmonary and Respiratory MedicineDual bronchodilation030228 respiratory systemQuality of LifeFormoterolbusinessTropanesRespiratory Medicine

researchProduct

Impact of quality of life related to foot problems : a case-control study

2021

AbstractFoot problems are highly prevalent conditions, being a frequent reason for medical and podiatric consultation. The aim of this study was to compare the differences of quality of life (QoL) related to foot health in people with and without the presence of foot problems. A case–control study was carried out in an outpatient centre, where a clinician recorded data related to sociodemographic and clinical characteristics. In addition, self-reported data on foot health-related quality of life were recorded using the Spanish version of the Foot Health Status Questionnaire. The sample consisted of 498 participants (249 cases and 249 controls), with a median age of 30 years and an interquar…

AdultMaleQuality of lifemedicine.medical_specialtyAdolescentScienceCalidad de vidaVitalityFoot problemsArticle03 medical and health sciencesYoung Adult0302 clinical medicineMedical researchQuality of lifeInterquartile rangeSurveys and QuestionnairesMedicineHumans030212 general & internal medicineDemografiaExerciseAgedMultidisciplinarybusiness.industryFootQCase-control studyRHealth carePieMiddle AgedFoot health status questionnaireExtremitatsSpain030220 oncology & carcinogenesisCase-Control StudiesPhysical therapyQuality of LifeMalaltiesMedicineFemaleGeneral healthSelf ReportbusinessFoot (unit)

researchProduct

Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection.

2007

Summary. Hepatitis C virus (HCV) infection is associated with a significant reduction of health related quality of life (QOL), the causes and mechanisms of which are still unknown. To explore whether treatment history could affect QOL, we examined patients with detectable HCV viraemia who had a different therapeutic background. Two hundred sixty-four consecutive subjects with chronic HCV infection and detectable viraemia were enrolled. Of these, 163 were untreated patients, 43 were relapsers, 58 were nonresponders (NR) to nonpegylated interferon (IFN) therapy. To assess QOL, three self-report instruments were employed: the Short Form-36 (SF-36), the Chronic Liver Disease Questionnaire (CLD…

AdultMaleQuestionnairesmedicine.medical_specialtyHealth StatusHepatitis C virusComorbidityAffect (psychology)Chronic liver diseasemedicine.disease_causeliver-specific quality of life nonresponse to treatment physical comorbidity quality of lifeWorld healthVirusQUALITY OF LIFEChronic hepatitisQuality of lifeSurveys and QuestionnairesVirologyInternal medicineHumansMedicineChronicAgedHepatologybusiness.industryHepatitis C ChronicMiddle Agedmedicine.diseaseHepatitis CComorbidityhumanitiesAdult Aged Comorbidity Female Health Status Hepatitis C; Chronic; drug therapy/virology Humans Interferons; therapeutic use Linear Models Male Middle Aged Quality of Life Questionnairesdrug therapy/virologyInfectious Diseasestherapeutic useHCVLinear ModelsPhysical therapyFemaleInterferonsbusiness

researchProduct

Health-related quality of life in epilepsy: findings obtained with a new Italian instrument

2008

The aim of the present study was to evaluate the Epi-QoL, a new Italian-specific measure of health-related quality of life (HRQOL) for adults with epilepsy; the clinical variables that affected the HRQOL score were also assessed. The Epi-QoL is a 46-item self-administered questionnaire focusing on six domains: Physical Functioning, Cognitive Functioning, Emotional Well-Being, Social Functioning, Seizure Worry, and Medication Effects. Eight hundred fifteen patients recruited from 24 secondary and tertiary Italian centers for the care of epilepsy were assessed. The results supported the reliability and validity of the Epi-QoL as a measure of HRQOL. The variables that significantly affected HR…

AdultMaleQuestionnairesmedicine.medical_specialtymedia_common.quotation_subjectHealth StatusMEDLINEHRQOL epilepsy questionnairepsychologySeverity of Illness IndexBehavioral NeuroscienceEpilepsyQuality of life (healthcare)epidemiology/psychologySurveys and QuestionnairesSeverity of illnessMedicineHealth Status IndicatorsHumansCognitive skillPsychiatrymedia_commonHealth related quality of lifeEpilepsybusiness.industryAdult Epilepsy; epidemiology/psychology Female Health Status Health Status Indicators Humans Italy; epidemiology Male Middle Aged Quality of Life; psychology Questionnaires Severity of Illness IndexMiddle Agedmedicine.diseaseComorbidityhumanitiesSettore MED/26 - NEUROLOGIANeurologyItalyQuality of LifeepidemiologyFemaleNeurology (clinical)Worrybusiness

researchProduct

"Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxa…

2010

BACKGROUND: No differences in response rate (RR), progression-free survival (PFS), overall survival (OS) and quality of life (QoL) were seen in patients randomly treated with biweekly oxaliplatin plus either fluorouracil/folinic acid or capecitabine. METHODS: We investigated the independent effect of baseline clinical characteristics and physical functioning (PF) domain on RR, PFS, and OS in 310 patients who completed the EORTC QLQ-C30 questionnaire. Multivariate analyses stratified by treatment were performed. An exploratory analysis was done by grouping patients with a PF score superior or equal to the highest quartile (n = 111), included between the highest and the lowest quartiles (n = …

AdultMalemedicine.medical_specialtyMultivariate analysisColorectal cancerSettore MED/06 - Oncologia MedicaKaplan-Meier EstimateGastroenterologyDisease-Free SurvivalCapecitabineTreatment Outcome; Prognosis; Aged 80 and over; Male; Retrospective Studies; Randomized Controlled Trials as Topic; Middle Aged; Kaplan-Meier Estimate; Colorectal Neoplasms; Female; Disease-Free Survival; Humans; Quality of Life; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials Phase III as Topic; Aged; Adult; Health Status Indicators; Multicenter Studies as TopicFolinic acidQuality of lifeInternal medicineAntineoplastic Combined Chemotherapy Protocols80 and overmedicineOverall survivalHealth Status IndicatorsHumansMulticenter Studies as TopicClinical TrialsRadiology Nuclear Medicine and imagingneoplasmsmetastatic colorectal canceroxaliplatin physical functioning statusAgedRandomized Controlled Trials as TopicRetrospective StudiesAged 80 and overbusiness.industryHematologyGeneral MedicineMiddle AgedPrognosismedicine.diseaseSurgeryOxaliplatinPhase III as TopicTreatment OutcomeClinical Trials Phase III as TopicOncologyQuartileQuality of LifeFemaleColorectal Neoplasmsbusinessmedicine.drug

researchProduct

Assessment of maximal handgrip strength: How many attempts are needed?

2017

BACKGROUND: Handgrip strength (HGS) is used to identify individuals with low muscle strength (dynapenia). The influence of the number of attempts on maximal HGS is not yet known and may differ depending on age and health status. This study aimed to assess how many attempts of HGS are required to obtain maximal HGS.METHODS: Three cohorts (939 individuals) differing in age and health status were included. HGS was assessed three times and explored as continuous and dichotomous variable. Paired t-test, intraclass correlation coefficients (ICC) and Bland-Altman analysis were used to test reproducibility of HGS. The number of individuals with misclassified dynapenia at attempts 1 and 2 with respe…

AdultSarcopeniaAdolescentsex differenceHealth Statusadult; aged; aging; Article; cohort analysis; dual energy X ray absorptiometry; dynamometer; female; four minute walk test; geriatric assessment; grip strength; health status; human; major clinical study; male; middle aged; muscle strength; outpatient; priority journal; reproducibility; sarcopenia; sex difference; six minute walk test; walk test; walking speed; X ray bone densitometer; Aged; Geriatric assessment; Muscle strength; Reproducibility of Results; Sarcopeniahealth statuswalking speedArticlesarcopeniaCohort StudiesYoung Adultmalesix minute walk testmiddle aged80 and overHumansfour minute walk testhumanMuscle StrengthreproducibilityGeriatric AssessmentX ray bone densitometerAgedAged 80 and overdual energy X ray absorptiometryHand StrengthMuscle strengthadultwalk testagingAge FactorsReproducibility of ResultsOriginal ArticlesdynamometerMiddle Agedcohort analysismajor clinical studyGeriatric assessmentfemaleCross-Sectional Studiespriority journalgrip strengthoutpatientOriginal Articlelihasvoima

researchProduct

Measurement Invariance and Construct Validity of the Satisfaction With Life Scale (SWLS) in Community Volunteers in Vietnam.

2022

Worldwide, the Satisfaction With Life Scale (SWLS) has become the most widely used measure of life satisfaction. Recently, an authorized Vietnamese-language version has been introduced. Using a convenience sample comprising community volunteers from Ho Chi Minh City (N = 1073), confirmatory support was found for the cross-national constancy of the one-dimensional structure underlying the SWLS. Corrected item–total polyserial correlations and Omega coefficient were satisfactory. Using multi-group confirmatory factor analysis, configural, metric, and scalar invariance of the SWLS factorial structure were tested by gender, age, marital status, income, and educational level. Strong evidence of …

EstatVolunteersPoblacióPsychometricsHealth Toxicology and MutagenesisPublic Health Environmental and Occupational HealthReproducibility of ResultsPersonal Satisfactionbehavioral disciplines and activitiesPsicologiaVietnamAnàlisi factorialQuality of LifeHumansSalutSatisfaction With Life Scale; subjective well-being; measurement invariance; confirmatory factor analysis; health status; marital status; income; Vietnamese populationPsicometriaFactor Analysis StatisticalInternational journal of environmental research and public health

researchProduct

Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: prospective cohort study

2016

Objective To evaluate the combined associations of diet, physical activity, moderate alcohol consumption, and smoking with body weight on risk of all cause and cause specific mortality. Design Longitudinal study with up to 32 years of follow-up. Setting Nurses’ Health Study (1980-2012) and Health Professionals Follow-up Study (1986-2012). Participants 74 582 women from the Nurses’ Health Study and 39 284 men from the Health Professionals Follow-up Study who were free from cardiovascular disease and cancer at baseline. Main outcome measures Exposures included body mass index (BMI), score on the alternate healthy eating index, level of physical activity, smoking habits, and alcohol drink…

GerontologyAdultMaleStatistics as TopicDisease030204 cardiovascular system & hematologyLower riskBody Mass IndexCohort Studies03 medical and health sciences0302 clinical medicineSex FactorsBiasEnvironmental healthNeoplasmsCause of DeathDiabetes MellitusMedicineHealth Status IndicatorsHumans030212 general & internal medicineLongitudinal StudiesProspective StudiesProspective cohort studyf body weightLife StyleCause of deathAged2. Zero hungerbusiness.industryResearchHazard ratioBody WeightAdult; Aged; Bias (Epidemiology); Body Mass Index; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus Type 2; Female; Health Status Indicators; Health Surveys; Humans; Longitudinal Studies; Male; Middle Aged; Neoplasms; Prospective Studies; Sex Factors; Statistics as Topic; United States; Body Weight; Cause of Death; Life Stylelifestyle factorsGeneral MedicineMiddle AgedHealth SurveysConfidence intervalUnited States3. Good healthDiabetes Mellitus Type 2Cardiovascular DiseasesBias (Epidemiology)FemalebusinessBody mass indexType 2Cohort study

researchProduct

The Italian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

2018

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Italian language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Each participating centre was asked to collect demographic, clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their paren…

GerontologyMaleParentsPatient Reported Outcome MeasurePsychometricsHealth StatusArthritisJuvenilePredictive Value of TestHealth StatuDisability Evaluation0302 clinical medicineMedicineImmunology and AllergyFunctional abilityAge of OnsetChildJAMARPatientPrognosisDisease status; Functional ability; Health Related Quality of Life; JAMAR; Juvenile idiopathic arthritis; Adolescent; Age of Onset; Arthritis Juvenile; Case-Control Studies; Child; Child Preschool; Cultural Characteristics; Female; Health Status; Humans; Italy; Male; Parents; Patients; Predictive Value of Tests; Prognosis; Psychometrics; Quality of Life; Reproducibility of Results; Rheumatology; Translating; Disability Evaluation; Patient Reported Outcome MeasuresCultural CharacteristicSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICAItalyChild PreschoolPredictive value of testsFemaleCase-Control StudiePsychometricHumanmedicine.medical_specialtyDisease statusAdolescentPatientsPsychometricsPrognosiImmunologyReproducibility of ResultDisease status; Functional ability; Health Related Quality of Life; JAMAR; Juvenile idiopathic arthritis; Rheumatology; Immunology and Allergy; Immunology03 medical and health sciencesJuvenile idiopathic arthritiQuality of life (healthcare)RheumatologyDisease status Functional ability Health Related Quality of Life JAMAR Juvenile idiopathic arthritis Adolescent Age of Onset Arthritis Juvenile Case-Control Studies Child Child Preschool Cultural Characteristics Female Health Status Humans Italy Male Parents Patients Predictive Value of Tests Prognosis Psychometrics Quality of Life Reproducibility of Results Rheumatology Translating Disability Evaluation Patient Reported Outcome MeasuresPredictive Value of Tests030225 pediatricsInternal medicineJuvenileHumansValidation StudiesPatient Reported Outcome MeasuresDisease statuPreschool030203 arthritis & rheumatologyCultural Characteristicsbusiness.industryArthritisReproducibility of ResultsHealth Related Quality of LifeTranslatingJuvenile idiopathic arthritismedicine.diseaseFunctional abilityArthritis JuvenileRheumatologyParentCase-Control StudiesQuality of LifeAge of onsetbusiness

researchProduct